Statistical Parametric Mapping Auswertung SPM Statistical Parametric Mapping http://www.fil.ion.ucl.ac.uk/fil.html

Atlas von Talairach & Tournoux Statistic Parametric Mapping   Auswertung allgemein: Realignment = Angleichung der einzelnen Bilder an den ersten Scan (intraindividuelle Bewegungskorrektur) Normalisierung = Transfromierung der Realing-Bilder in den Stereotaktischen Raum (z.B. Talairach & Tournoux; interindividuelle Korrektur) Smoothing = Filtern Statistik: Regression, Kontraste (Varianzanalyse...) oder t-tests Korrektur für multiple Vergleiche über Größe der Pixelcluster

+ Object Memory Condition Object Control Condition 500 msec 1500 msec 3000 msec Object Memory Condition Object Control Condition Smith & Jonides 1997 time

realignment & motion correction Statistical Parametric Map image data parameter estimates design matrix kernel realignment & motion correction General Linear Model model fitting statistic image random field theory smoothing normalisation Statistical Parametric Map anatomical reference corrected p-values

Lineare Transformationen

Nicht-lineare Transformationen

realignment & motion correction Statistical Parametric Map image data parameter estimates design matrix kernel realignment & motion correction General Linear Model model fitting statistic image random field theory smoothing normalisation Statistical Parametric Map anatomical reference corrected p-values

In fact the Gaussian values for 12 13 14 15 and 16 are: 0. 1174 0 and the data values for the same points are: 1.0645 0.3893 0.3490 -0.6566 -0.1946 We then multiply the Gaussian values by the values of our data, and sum the results to get the new smoothed value for point 14. Thus, the new value for point 14 is ... + 0.1174*1.0645 + 0.1975*0.3893 + 0.2349*0.3490 + 0.1975*-0.6566 + 0.1174*-0.1946 + ...

realignment & motion correction Statistical Parametric Map image data parameter estimates design matrix kernel realignment & motion correction General Linear Model model fitting statistic image random field theory smoothing normalisation Statistical Parametric Map anatomical reference corrected p-values

realignment & motion correction Statistical Parametric Map image data parameter estimates design matrix kernel realignment & motion correction General Linear Model model fitting statistic image random field theory smoothing normalisation Statistical Parametric Map anatomical reference corrected p-values

1st level 2nd level analyse 1st level analyse: Entweder eine VP oder alle VPn mit allen Bildern in eine Analyse (DF!) 2nd level analyse: Jede VP geht mit einem Bild in die Analyse ein (reduzierte DF!). Korrigierte P Werte? p uncorrected: 0.001 p corrected: 0.05 (FWE / FDR)

http://ric.uthscsa.edu/td_applet/