Sexualsteroid response elements LDL Rezeptor Lipoproteinlipase e NOS ACE System GABA Rezeptor Myelinscheiden NFkB Lunge Gewicht.

Präsentation zum Thema: "Sexualsteroid response elements LDL Rezeptor Lipoproteinlipase e NOS ACE System GABA Rezeptor Myelinscheiden NFkB Lunge Gewicht."—  Präsentation transkript:

1 sexualsteroid response elements LDL Rezeptor Lipoproteinlipase e NOS ACE System GABA Rezeptor Myelinscheiden NFkB Lunge Gewicht

2 Geschlechtsspezifische Hypercholesterinämie

3 Geschlechtsspezifische Hypertonie Östrogenmangelbedingte Hypertonie Progesteronmangelbedingte Hypertonie

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5 Estradiol stimulates eNOS not only in the uterus but also in the smooth muscles of blood vessels working like a nitro containing drug and protecting the endothelium

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9 Verordnungsrate Psychopharmaka 400 300 200 100 0<3535 - 3940 - 4445 - 4950 - 5455 - 59>60 pro 1000 Frauen bzw. Männer FrauenMänner

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12 Neurosteroid synthesis-mediated regulation of GABA(A) receptors: relevance to the ovarian cycle and stress. Maguire J, Mody I J Neurosci. 2007 Feb 28;27(9):2155-62. Progesterone (5 mg/kg, twice daily) upregulates the expression of GABA(A)R delta subunits and enhances the tonic inhibition mediated by these receptors in dentate gyrus granule cells (DGGCs). These changes in males as well as ovarian cycle-induced changes in females can be blocked by finasteride, an antagonist of neurosteroid synthesis from progesterone.

13 inhibierender GABA Neurotransmittor hemmt präpuberträre GnRH- Freisetzung Endocrine Reviews 22,111(2001)

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15 THE LANCET – Vol 358 Sep 8, 2001

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17 Gender-specific diseasesKnown antigens Addison´s disease 21-hydroxylase Coeliac diseaseTissue transglutaminase Type 1 diabetesGAD-65, insulin, IA-2A Graves´hyperthyroidismThyroid-stimulating- hormone receptor Hashimoto´s thyroiditisThyroid peroxidase, thyroglobulin Myasthenia gravisAcetylcholine receptor Goodpasture´s syndrome TypeIV collagen Pemphigus vulgarisDesmoglein 3 Pernicious anaemiaH/KATPase, intrinsic factor Primary biliary cirrhosisE2 PDC VitiligoTyrosinase, SOX-10 Multiple sclerosis Myelin basic protein, myelin oligodendritic glycoprotein

18 Systemic diseases Systemic lupusSpliceosomal snRNP, Ro/La erythematosus(SSA/SSB) particle, histone and native DNA Sjögren´s syndromeRo/La ribonuclear particle, muscarinic receptor Rheumatoid arthritisCitrillunated cyclic, peptide, IgM Dermatomyositis/polymyositist-RNA synthetases Diffuse systemic sclerosisTopoisomerase Limited systemic sclerosis Centromere proteins (CREST)CREST= calcinosis, Raynaud´s phenomenon, oesophageal dysmotility, sclerodactyly, and telangiectasia.

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20 Nat Med. 2007 Mar;13(3):245-6

21 SLEEP APNOE SYNDROM NIMMT IN MENOPAUSE ZU Block AJ et al. Am J Med 1980; 69:75-79 Leech JA et al. Chest 1988; 94:983-988

22 60% OF POSTMENOPAUSAL WOMEN HAD NOCTURAL DESATURATION, HYPOPNEAS, APNEAS, WHEREAS ONLY 11% OF PREMENOPAUSAL WOMEN HAD SUCH EVENT Block AJ et al. Am J Med 1980; 69:75-79

23 IN PCO PATIENTINNEN 20 – 44% SCHAFAPNOE Vgontzas AN et al. J Clin Endocrinol Metab 2001; 86:517-520

24 PROGESTERON ERHÖHT GENIOGLOSSALE MUSKELAKTIVITÄT Popovic RM et al. A Appl Physiol 1998; 84:1055-1062

25 ALKOHOL REDUZIERT DIE GENIOGLOSSALE MUSKELAKTIVITÄT IN DER FOLLIKELPHASE, NICHT JEDOCH IN LUTEALPHASE Leiter JC et al. Am Rev Respir Dis 1987, 135:383-386

26 PROGESTERON SUBSTITUTION VERBESSERT PRÄMENSTRUELLES ASTHMA Lancet 1988; 2:370

27 ASTHMA CHRON. INFLAMMATION DER LUFTWEGE MIT DEREN EINSCHRÄNKUNG FRAUEN HÄUFIGER BETROFFEN PRÄMENSTRUELLE ZUNAHME

28 ASTHMA ERHÖHTE IgE KONZENTRATION EOSINOPHILE Th2 ZYTOKINE VERMEHRT

29 ÖSTRADIOL VERSCHIEBT ZYTOKINE IN Th2 RICHTUNG REGT NO SYNTHASE AN

30 DIAMINOXYDASE IN EXTRAUTERINEN ORGANEN DURCH ÖSTROGEN GEHEMMT: URTIKARIA RHINITIS LIDÖDEM REIZDARM DYSMENORRHOE

31 DIAMINOXIDASE DURCH ALKOHOL GEHEMMT

32 HISTAMIN RHINITIS ALLERGICA ASTHMA BRONCHIALE URTIKARIA TACHYKARDIEN INTESTINALE BESCHWERDEN SCHWELLUNG DER AUGENLIDER