Projekt FLARE nRolle von Flammschutzmitteln als endokrin aktive Substanzen in der Umwelt (NFP50: Hormonaktive Stoffe: Bedeutung für Menschen, Tiere und.

Präsentation zum Thema: "Projekt FLARE nRolle von Flammschutzmitteln als endokrin aktive Substanzen in der Umwelt (NFP50: Hormonaktive Stoffe: Bedeutung für Menschen, Tiere und."—  Präsentation transkript:

1 Projekt FLARE nRolle von Flammschutzmitteln als endokrin aktive Substanzen in der Umwelt (NFP50: Hormonaktive Stoffe: Bedeutung für Menschen, Tiere und Ökosysteme) Partner nSAFE (Patricia Holm) nPHEBRO (Walter Giger und Hans Peter Kohler) Umsetzung nZeithorizont: Frühjahr 2003 nFinden von Hotspots (Projekte SAFE / Fischnetz) èendokrine Aktivität des Flusswassers (YEAST) èerhöhte Vitellogenin Levels Bachforellen nAnalyse von Leber/Galle von Bachforellen nIdentifizierung von Metaboliten von bromierten Flammschutzmitteln

2 FLARE FLARE Brominated flame retardants and their transformation products: Occurrence in the environment and human exposure to these endocrine active components Andreas Gerecke, Peter Schmid, Martin Kohler, Swiss Federal Laboratories for Materials Testing and Research (EMPA), 8600 Dübendorf

3 Brominated Flame Retardants Technical Properties nBFR are additives for plastics and textiles (%-range!) nBFR inhibit / suppress combustion nBFR are now the second most used additive for plastics nAnnual production over 150,000 tons, demand increasing Environmental Impact - Is the PCB disaster being repeated? nSome BFR and their metabolites are endocrine disruptors nSome BFR are proven to be persistent organic pollutants (POPs) nBFR in human milk rose from < 1 ng/g lipid to 200 ng/g lipid (USA)

4 Brominated Flame Retardants Hexabromocyclododecane nPolystyrene foam and expanded polystyrene nLittle is known on fate and toxicity Polybrominated Diphenylethers nPlastics and textiles - persistent organic pollutants nPentaBDE to be banned, DecaBDE as alternative? Tetrabromobisphenol A nElectronic circuit boards - covalently bound nSimilar structure to bisphenol A and T 3 /T 4

5 Known Effects of Brominated Flame Retardants nEndocrine disrupting effects found for TBBPA, PBDE and metabolites nPBDE & metabolites are ER alpha and ER beta receptor agonists nPBDE & TBBPA: competition with thyroxine T 3 /T 4 nImmunotoxic effects (reduced production of IgG by BDE-47) nDevelopmental toxicity (behavior aberration in mice by BDE-99) nMost data available for mammals & assays / little known about fish Endocrine Disrupting Effects Transformation products of BDE-199 mimicking T 3 /T 4

6 Goals nInvestigate environmental levels and transformation products of brominated flame retardants in the aquatic environment Implementation of an effect driven approach - analysing fish & environment where effects of ED are found Task I nDevelopment of analytical methods for BFR & transformation products Task II nCollecting and analysing relevant samples for the target compounds and for transformation products Task III nCorrelation to effects and implementation of the results Goals and Tasks

7 SAFE nEndocrine disruption in Switzerland: Assessment of fish exposure and effects (SAFE): Patricia Holm, Helmut Segner, Armin Peter PHEBRO nPhenolic and brominated contaminants in wastewater and in the aquatic environment (PHEBRO): Walter Giger, Hans-Peter Kohler Aquanet & various Institutions nEAWAG, BAG, BUWAL, FAW Related Activities at EMPA nDioxins, coplanar PCB and BFR in various matrices: Markus Zennegg nBrominated flame retardants (BFR) - Transfer from Building Materials and Textiles to Indoor Air and Human Exposure Assessment Partners

8 Thank you for your attention