How effective are heart valve transplants from organ donors of 65-70 years of age K. Grosse 1, R. Meyer 2, C. Wesslau 3, D. Bösebeck 1, R. Hetzer 2, G.

Präsentation zum Thema: "How effective are heart valve transplants from organ donors of 65-70 years of age K. Grosse 1, R. Meyer 2, C. Wesslau 3, D. Bösebeck 1, R. Hetzer 2, G."—  Präsentation transkript:

1 How effective are heart valve transplants from organ donors of 65-70 years of age K. Grosse 1, R. Meyer 2, C. Wesslau 3, D. Bösebeck 1, R. Hetzer 2, G. Kirste 1 1 Deutsche Stiftung Organtransplantation, Germany 2 Deutsches Herzzentrum Berlin, Germany 3 Stiftung Europäischer Gewebebanken Berlin, Germany Deutsches Herzzentrum Berlin

2 Organ Donors over 65 Years of Age in Germany % year

3 Above the Age Limit of 65 Years ( Test Group, n=100) Below the Age Limit of 65 Years ( Control Group, n=380) Valves, total [n]200760 Valve Grafts [n]100 (50%)379 (50%) Aortic Valve Grafts [n] 15 (15%)113 (30%) Pulmonary Valve Grafts [n] 85 (85%)266 (70%) Heart Valve Donors (1999-2004)

4 [Years] former Age Limit Aortic Valve Allografts Pulmonary Valve Allografts Morphologically Optimal (code 1-2) Acceptable (code 3-5) Unsuitable (code 6) for Transplantation* 4 th Decade of Life [%] Heart Valve Donors (1999-2004) *Quality Codes of the Bio Implant Services (BIS)

5 Organ Donors Heart Donors Heart Valve Donors Pulmonary Valve Grafts Aortic Valve Grafts Donors/Valves [n]99849211 Distribution Of Gender [n] ♀ 42 ♂ 57 ♀ 4 ♂ 4 ♀ 21 ♂ 28 ♀ 11 ♂ 10 ♀ Mean Age at Donation [Years] ♀+♂ 67 ♀ 68 ♂ 65,5 ♀+♂ 67 ♀ 66,5 ♂ 67 66 Heart Valve Grafts from Elderly Organ Donors* (2005-2009) *from 65 to 70 years of age

6 Total Recipients Transplanted Recipients Successful** Heart Valve Replacement Recipients [n]221914 (74%) Distribution Of Gender [n] ♀ 7 ♂ 15 ♀ 6 ♂ 13 ♀ 6 ♂ 8 Mean Age at Transplantation [Years] ♀ 25 ♂ 36 ♀ 25 ♂ 31,5 ♀ 25 ♂ 28 Recipients of the Heart Valve Grafts from Elderly Organ Donors* (2005-2009) *from 65 to 70 years of age **without morphological and functional alteration of the graft 1 year after replacement

7 These results clearly demonstrate, that heart valve grafts from organ donors between 65 and 70 years of age can safly be used with good longterm success Conclusion

8 Klinik für Thorax-, Herz- und Gefäßchirurgie, Johann Wolfgang Goethe-Universität Frankfurt am Main Deutsche Gesellschaft für Gewebespende, Hannover Bio Implant Services, Leiden Klinik für Herz- und thorakale Gefäßchirurge, Universitätsklinikum Schleswig-Holstein Campus Lübeck Deutsches Herzzentrum München Universitair Medisch Centrum St. Radboud, Nijmegen Erasmus Universitair Medisch Centrum, Rotterdam Klinik für Thoax- und Herz-Gefäßchirurgie, Universitätsklinikum des Saarlandes Sana Herzchirurgie Stuttgart Acknowledgement