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Veröffentlicht von:Maximilian Otto Geändert vor über 8 Jahren
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Transkriptionelle Kontrolle der B-Zellplastizität und Onkogenese durch Pax5 Meinrad Busslinger Institut für Molekulare Pathologie, Wien
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Transkriptionsfaktoren kontrollieren die Genexpression Pax5
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B-Zelldifferenzierung Pax5 definiert die Identität der B-Zelle
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Deletion of the Pax5 gene in mature B cells conditional Pax5 allele Cre recombinase transgene
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Tumor formation upon Pax5 loss in B cells Kaplan Meier survival plot Cobaleda et al. (2007) Nature
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Tumors by dedifferentiation to early progenitor cell stage Question: dedifferentiation also under non-oncogenic conditions? Pax5 loss Pax5 = tumor suppressor gene of B-lymphoid lineage tumor with immunoglobulin rearrangements
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B cell plasticity in response to Pax5 loss
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+ immunoglobulin rearrangements Journey of the mature Pax5-deficient B cells
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Pax5 = critical regulator of B cell identity Developmental plasticity of mature B cells
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gene deletion gene addition Dedifferentiation versus Transdifferentiation
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Conversion of fibroblasts into pluripotent stem cells Ectopic expression of 4 transcription factors Mouse: Okita et al. Nature 448, 313-317 Wernig et al. Nature 448, 318-324 Human:Takahashi et al. Cell 131, 861-872 Yu et al. Science 318, 1917-1920
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